To elaborate on the potential mechanism of circ_0000098/miR-1204 axis in HCC, we predicted the potential target gene of miR-1204 by the TargetScan tool (http://www.targetscan.org/) (17) and discovered that there were complementary binding sites between miR-1204 and ALX4 3’-UTR (Figure 5A). Here, ALX4 is linked to hepatocellular carcinoma.