In the background of chromosome 3p loss, there is frequent loss of heterozygosity in four aberrant tumor suppressor genes: Von Hippel-Lindau Tumor Suppressor (VHL), Polybromo 1 (PBRM1), SET Domain Containing 2 (SETD2), and BRCA1 Associated Protein 1 (BAP1) within ccRCC. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.