CCL4 and nonpapillary renal cell carcinoma: In this study, we identified a potential immune-related candidate, CCL4, associated with remodeling the TME derived from the intersection of data from the GEO, TCGA and the ImmPort databases using integrated bioinformatics analysis, which is definitely the first work to imply the molecular characteristics and value of CCL4 in tumor progression, immune infiltration and immunotherapy response in ccRCC.