To determine the impact of CCL4 expression levels on the somatic mutation landscape in 336 KIRC samples, the R package “maftools” was applied to find that 83.33% of the samples were detected to have at least one type of mutational events among the top 20 mutated genes in ccRCC (Supplementary Figure 4). The gene discussed is CCL4; the disease is nonpapillary renal cell carcinoma.