The Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) showed a higher female predominance of PAH irrespective of BMPR2 status, and found that the female-to-male ratio for PAH was 3.9:1 in races other than whites, black and Hispanic [21]. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.