Among these five genes, CXCL3 and PLEKHF1 have been reported in breast cancer related studies, among which CXCL13 has been reported to be highly-expressed in breast cancer and significantly correlated with lymph node metastasis, distant metastasis, and disease staging (Jiang et al., 2020). This evidence concerns the gene CXCL3 and metastatic malignant neoplasm in the lymph nodes.