Among these five genes, CXCL3 and PLEKHF1 have been reported in breast cancer related studies, among which CXCL13 has been reported to be highly-expressed in breast cancer and significantly correlated with lymph node metastasis, distant metastasis, and disease staging (Jiang et al., 2020). The gene discussed is PLEKHF1; the disease is metastatic malignant neoplasm in the lymph nodes.