Breast cancer cell-derived exosomal oncogenic miRNAs, such as miR-105 suppress endothelial tight junction ZO-1 expression, contributing to increased metastasis by impairing blood vessel integrity and enhancing vascular permeability, have been implicated in the angiogenic and extracellular matrix remodeling of the TME [10,106]. This evidence concerns the gene TJP1 and breast carcinoma.