HIF1A and neoplasm: Several studies have indicated that exosomes derived from tumor cell play a critical role in tumor metastatic pathophysiology by utilizing tumor-signaling pathways such as caveolin-1, HIF-1a, miR-21, miR-105, miR-148b, miR-210, β-catenin and oncogenic kinases (e.g., mutated EGFR, RAS and MAP kinases) [49,116–120].