For example, miR-204 can protect early sepsis by inhibiting the release of proinflammatory factors through GSKJ4, and miR-204 can also inhibit the NF-κB pathway and FOXK2 to downregulate miR-21, thereby improving the occurrence of sepsis, but its effect on sepsis-induced ALI is not yet known. This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.