The RB signalling network is made up of 3 pocket proteins (RBL1, RBL2 and RB1) that together firmly legalize cell cycle (G1/S) evolution and whose genetic polymorphism might very well underpin cell type specific redundancy or operational recompense in tumour suppression of concurrent suppression with RBL1 (p107) needed to enable tumour formation [12]. The gene discussed is RBL2; the disease is neoplasm.