Natriuretic peptide, especially B-type diuretic peptide (BNP), N-terminal pro-B-type diuretic peptide (NT-BNP), central regional atrial natriuretic peptide (MR-proANP), and cardiac troponin are established blood biomarkers in the diagnosis of heart failure and prognosis of HF-related outcomes [16, 30, 31]. This evidence concerns the gene NPPB and heart failure.