PVT1 and cancer: Previous meta-analysis [29] also reported that cancer patients with high PVT1 expression had a poorer overall survival (HR = 2.07, 95% CI: 1.40-2.74, P = 0.000) and a worse disease-free survival (HR = 2.10, 95% CI: 0.96-3.23, P = 0.000).