However, as their conditions improved, CD4 values and CD4/CD8 ratios increased, along with a concomitant decrease in inflammatory cytokines, IL-6 and TNF-alpha levels, which suggested that hUCB-MNCs could alter the imbalance of T-cell subsets, modulate the cellular immune responses, and suppress the inflammatory responses in patients with MSA. Here, CD4 is linked to multiple system atrophy.