It is known that chronic inflammation has been shown as a key player at different stages of COPD, and a prominent signaling pathway for acute and chronic inflammation is the activation of the caspase 1 inflammasomes, which are reported as a group of cytosolic protein complexes formed to mediate host immune responses to microbial infection and cellular damage, among which NLRP3, AIM2, and NLRC4 are of great importance in the context of COPD for their activities in modulating immune responses [34–36]. Here, AIM2 is linked to chronic obstructive pulmonary disease.