Exploration of available transcriptomic datasets revealed crosstalk genes (e.g., RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, FIBP, PSMB2, SELPLG, and SEC61G) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and VEGF signaling pathway) as the top candidate molecular linkage mechanisms between atherosclerosis and periodontitis. This evidence concerns the gene SUMO1 and periodontitis.