Considering the three significant modules of the atherosclerosis-GSE23746 dataset, two core crosstalk genes Formin Homology 2 Domain Containing 1 (FHOD1) and RAS Guanyl Releasing Protein 2 (RASGRP2) were identified in the blue module (Figure 11(a)), as well as four core crosstalk genes VAMP7, Sorting Nexin 3 (SNX3), Cell Cycle Progression 1 (CCPG1), and PEST Proteolytic Signal Containing Nuclear Protein (PCNP) were identified in the green module (Figure 11(b)), while two core crosstalk genes (HMGB1 and SUMO1) were identified in the turquoise module. The gene discussed is HMGB1; the disease is atherosclerosis.