A group of atherosclerosis-known genes, such as HMGB1, TNF Superfamily Member (TNFSF) 13B, and IL-18, were upregulated, while another group of atherosclerosis-known genes, such as CD14 Molecule (CD14), Integrin Subunit Beta 2 (ITGB2), and IL1B were downregulated, in the PBMs of periodontitis-GSE46190 dataset (Figure 3(b)). Here, HMGB1 is linked to periodontitis.