NR4A1 and neoplasm: Megestrol is one of the commonly used drugs; it can effectively regulate hormones secreted by pituitary stimulation, inhibit the action of the female hormone secretion, at the same time also can block the body's hormone receptors from binding to estrogen, thus inhibiting the proliferation and diffusion of tumor cells, but also can promote the body cell differentiation, improve the clinical symptoms and prolong survival time [15, 16].