IGF1R and pachyonychia congenita: To elucidate the relationship among miR-139-5p, IGF1R, and circRNF13 in PC progression, we conducted the luciferase reporter assay on MIA-PaCa-2 cell that successfully transfected with the mutant of IGF1R or circRNF13, respectively (Figures 4(a) and 4(b)).