The Transwell test results of the cells showed that WIP1 overexpression promoted the invasion ability of PCa cells, miR-145-5p mimics inhibited the invasion ability of PCa cells, and WIP1 could reverse the invasion inhibition ability of miR-145-5p (Figures 6(e) & 6(f)). The gene discussed is PPM1D; the disease is posterior cortical atrophy.