The average mutation burden of PTEN, APOB, FRAS1, KDM6A, DDR2, TTK, NRAS, TP53, PTPRB, MPL, FCRL1, HN1, and SFN gradually increased from CHB and LC to HCC (Figures 3(a) and 3(b)). Here, TP53 is linked to hepatocellular carcinoma.