The most commonly mutated genes among patients with CHB, LC, and HCC included DST, ZFHX4, SYNE2, PEG3, ASPM, KEAP1, KDM6A, PTPRB, FRAS1, APOB, MAP1B, RPS6KA3, USP9X, BRD7, SPAG17, ACVR2A, IDH2, AR, TERT, TP53, TGFBR2, EP300, STAT3, and DDR2. The gene discussed is SPAG17; the disease is hepatocellular carcinoma.