The optimal HCC gene panel included DST, SYNE2, APOB, KDM6A, USP9X, SPAG17, TERT, TP53, AMPH, EP300, TTK, CCND1, FCRL1, IL6ST, PTEN, SFN, STK11, and NRAS. The gene discussed is CCND1; the disease is hepatocellular carcinoma.