The average mutation burden of PTEN, APOB, FRAS1, KDM6A, DDR2, TTK, NRAS, TP53, PTPRB, MPL, FCRL1, HN1, and SFN gradually increased from CHB and LC to HCC (Figures 3(a) and 3(b)). The gene discussed is PTPRB; the disease is hepatocellular carcinoma.