The average mutation burden of PTEN, APOB, FRAS1, KDM6A, DDR2, TTK, NRAS, TP53, PTPRB, MPL, FCRL1, HN1, and SFN gradually increased from CHB and LC to HCC (Figures 3(a) and 3(b)). This evidence concerns the gene MPL and laryngotracheoesophageal cleft.