The most commonly mutated genes among patients with CHB, LC, and HCC included DST, ZFHX4, SYNE2, PEG3, ASPM, KEAP1, KDM6A, PTPRB, FRAS1, APOB, MAP1B, RPS6KA3, USP9X, BRD7, SPAG17, ACVR2A, IDH2, AR, TERT, TP53, TGFBR2, EP300, STAT3, and DDR2. The gene discussed is STAT3; the disease is hepatocellular carcinoma.