The average mutation burden of PTEN, APOB, FRAS1, KDM6A, DDR2, TTK, NRAS, TP53, PTPRB, MPL, FCRL1, HN1, and SFN gradually increased from CHB and LC to HCC (Figures 3(a) and 3(b)). Here, NRAS is linked to laryngotracheoesophageal cleft.