DES and familial dilated cardiomyopathy: The genetic etiology of DCM is broad and variants are identified in genes encoding sarcomeric proteins, cytoskeleton, ion channels, nuclear envelope, and intercellular junction proteins such as TTN, LMNA, DSP, MYH7, FLNC, TNNT2, RBM20, DES, TPM1, FLNC, and DMD. (Herman et al., 2012; McNally et al., 2013; Mestroni and Taylor, 2013; Akinrinade et al., 2015).