An analysis of the relationship between osteosarcoma development and KIF21B using bioinformatics analysis showed that knockdown of KIF21B inhibited cell proliferation and reduced tumor formation in vivo by modulating the PI3K/AKT pathway and that KIF21B was an independent prognostic factor in osteosarcoma patients (Ni et al., 2020). This evidence concerns the gene AKT1 and osteosarcoma.