TYROBP and osteosarcoma: Jiang et al. (2021) created a hypoxia gene-based signature to predict the survival in childhood osteosarcoma. Wang et al. developed a new classification system of osteosarcoma based on immune features and identified TYROBP as a key immune regulatory gene (Wang X. et al., 2021). Qi et al. identified a prognostic signature of osteosarcoma based on 14 autophagy-related genes that can guide clinical decisions in treating osteosarcoma (Qi et al., 2021).