RYR2 and catecholaminergic polymorphic ventricular tachycardia: In 50–65% of CPVT cases genetic mutations are identified in RYR2, a gene encoding the main intracellular calcium channel of cardiomyocytes, and much less frequently in others genes that are also related to calcium homeostasis [CASQ2, CALM1, CALM2, CALM3, TRDN, TECRL (Priori et al., 2002; Ackerman et al., 2011; Ackerman et al., 2011; Nyegaard et al., 2012; Roux-Buisson et al., 2012; Devalla et al., 2016; Jensen et al., 2018)].