Several previous studies have identified miR-92a as being implicated in dysregulation and suppression of tumour suppressors, including PTEN (Xiao et al., 2008) and PHLPP2 (Rao et al., 2012) in MCL models and VHL in CLL B-cells (Ghosh et al., 2009). The gene discussed is PTEN; the disease is B-cell chronic lymphocytic leukemia.