PDGFRA (platelet derived growth factor receptor alpha) mutations cause a variety of heterogeneous gastrointestinal mesenchymal tumors (Ricci et al., 2015), and TKIs inhibiting the most common driving mutations in KIT or PDGFRA might have brought about radical changes in treating gastrointestinal stromal tumors in the past 20 years (Zalcberg, 2021). The gene discussed is PDGFRA; the disease is gastrointestinal stromal tumor.