HDAC6 and colorectal carcinoma: For example, the cytosolic histone deacetylase 6 (HDAC6) served as a tumor suppressor in hepatocellular carcinogenesis (Yang et al., 2019), while another study revealed that the HDAC6 inhibitor significantly suppressed the proliferation and viability and induced apoptosis in CRC cells, where autophagy activation was observed (Chen et al., 2019).