TET1 and alcoholic liver diseases: Finegersh et al. (2015) demonstrated that repeated intermittent alcohol exposure increased Tet1 mRNA expression in the NAc but not in cortex in a mouse AUD model. However, in a recently published study, Ji et al. (2019) found that ethanol exposure to liver cells reduces Tet1 and 5hmC formation is involved in hepatocyte apoptosis in alcoholic liver disease progression. We found no changes in Tet1-3 mRNA levels or DNMT activity in NAc in the rat AA model.