It was found that there was an association between the IL23R rs11209026-GG genotype and more severe PsO, and there were significant associations between the three SNP genotypes (IL12B rs6887695-CC, IL12B rs3212227-CC, and IL23R rs2201841-GG) and T2DM. The gene discussed is IL12B; the disease is type 2 diabetes mellitus.