Quaranta et al. (2009) found that CDKAL1 SNP rs6908425 was significantly correlated with PsO by analyzing the PsO dataset. The association with PsO and CD was completely independent of the association with T2DM. Gene expression studies showed that there is no CDKAL1 transcript in skin keratinocytes, but CDKAL1 is expressed in large quantities in immune cells. CDKAL1 expression is especially present in CD4+ and CD19+ lymphocytes. The gene discussed is CDKAL1; the disease is type 2 diabetes mellitus.