This study identified 7 PsO and CD-shared susceptibility loci outside the HLA region (9p24 near JAK2, 10q22 near ZMIZ1, 11q13 near PRDX5, 17q21 near STATS3, 17q21 near SOCS1, 19p13 near YDJC, and 22q11 near FUT2), and four reported PsO and CD risk loci (IL23R, IL12B, REL, and TYK2) were verified. Here, PRDX5 is linked to Cowden disease.