IL4R and Alzheimer disease: d) The IL4R polymorphisms have been previously determined to be related to AD: 3112C > T, 1803T > C, 327C > A, 326A > C, and 186G > A. Fukai et al. (2004) explored whether these polymorphisms are related to PsO in the Japanese population and found that IL4R 326A > C and 186G > A variants are significantly associated with PsO.