Shroom family member 3 (SHROOM3) also appeared to be very significant in our GAWS studies on cystatin C. It plays an important role in mammalian kidney development and human kidney disease including CKD and ESRD through estimated glomerular filtration rate based on creatinine (eGFRcrea) (Kottgen et al., 2009; Boger et al., 2011). This evidence concerns the gene CST3 and kidney disorder.