INPP5B and hepatocellular carcinoma: In addition, Zhang et al. discovered the key potential transcription axis of CTCF/POLR2A—SYNJ2/INPP5B in metabolic programs based on the ChIP-seq data set, speculated that CTCF/POLR2A could directly dysregulate SYNJ2 levels and that increased SYNJ2 would affect HCC development via metabolic perturbation pathways (Zhang et al., 2021).