Interestingly, patients with COVID-19- associated atypical HUS, who underwent genetic testing, were found to harbour genetic complement dysregulation, and 2 patients were positive for antibodies against complement factor H. Although limited, available data suggest that COVID-19 is a potential trigger for HUS, in accordance with previous data on complement-mediated aHUS precipitated by viral infections such as Influenza. Here, CFH is linked to hemolytic-uremic syndrome.