TNF and rheumatoid arthritis: Employing the dialogue on reverse engineering assessment and methods (DREAM), a Gaussian regression model was created to predict the changes in the DAS28 scores of patients with RA receiving tumor necrosis factor-α (TNF-α) inhibitor therapy, by using the expression patterns of genes involved in insulin secretion (PDZD2), immune response (CD84), and eicosanoid synthesis (PLA2G4A).