STAT3 and rheumatoid arthritis: found that CD14+ monocytes displayed mitochondrial respiration, biogenesis, enhanced glucose consumption and mitochondrial morphological changes, and they enhanced gene expression of key glycolytic enzymes, such as HIFIα, HK2, and PEKFB. Blocking of STAT3 inhibits this forced glycolytic flux along with inflammation and may represent a potential therapeutic approach for preclinical RA (103).