T cells, both CD4+ and CD8+, in the NET-rich TME of animals that underwent I/R expressed significantly higher levels of markers of exhaustion (PD-1, Tim3, Lag3) compared to the tumor infiltrating T cells in mice who had not been subjected to I/R or who had received daily DNAse injection in addition to I/R (Figures 1C, D). The gene discussed is HAVCR2; the disease is neoplasm.