Furthermore, previous studies have shown that gene polymorphisms are associated with mannose-binding lectin-associated serine protease 2 (MASP-2) and MBL expression levels, and are able to cause immunodeficiency, promote infection progression, and influence several infections in VL (23–25), since those genes are related to the lectin pathway activation (26). This evidence concerns the gene MASP2 and immunodeficiency disease.