Moreover, selective inhibition of STAT3 using STATTIC, a small molecule JAK/STAT inhibitor (99), in LPS-stimulated RA CD14+ monocytes results in almost complete suppression of the expression of inflammatory markers (such as TNF-α, IL-6, IL-1β, IL-27) and chemokines (such as CXCL10 and CXCL11), and it further diminishes the expression of the PFKFB3, HK-II, and GLUT1 proteins (100). The gene discussed is TNF; the disease is rheumatoid arthritis.