PFKFB3 inhibition reduces the expression of the pro-inflammatory cytokines IL-8 and IL-6, and of the chemokines CCL2 and CXCL10 in RA FLSs; also, PFKFB3 inhibition prevents cell proliferation, migration, and invasion (93). The gene discussed is CXCL8; the disease is rheumatoid arthritis.