PFKFB3 and arthritic joint disease: By contrast, Saeki N’s research demonstrated the mRNA expression levels of Pfkfb1 and Pfkfb3 are up-regulated in murine arthritis tissue-derived synovial macrophages (ADSM) treated with arthritis tissue-derived SF (ADSF)-CM compared to the levels in ADSM treated with ADSM-CM and normal tissue-derived SF (NDSF)-CM (94).