Moreover, OSM significantly induces angiogenic networks formation, adhesion, and invasion mechanisms that are accompanied by changes in the bioenergetic profile of cells, in which OSM significantly increases the extracellular acidification rate (ECAR)/OCR ratio of primary RA FLSs (favoring glycolysis) and it induces the expressions of GLUT1 and of the key glycolytic rate-limiting enzymes HK-II and PFKFB3 (67). This evidence concerns the gene PFKFB3 and rheumatoid arthritis.