RA FLSs pretreated with 2-DG and then cultured in the presence of platelet-derived growth factor-BB (PDGF-BB) for 4 days, exhibited a significantly diminished cell proliferation rate as measured by an MTT assay; the cellular levels of cell migration, IL-6, and MMP-3 were also significantly reduced (88). The gene discussed is IL6; the disease is rheumatoid arthritis.