The PFKFB3 inhibitor 3PO (3-[3-pyridinyl]-1-[4-pyridinyl]-2-propen-1-one) on healthy CD4+ T cells mimics the slow glycolytic breakdown of RA T cells, which in turn increases the transcript level of SH3PXD2A (110). The gene discussed is PFKFB3; the disease is rheumatoid arthritis.