Mimicking RA T cells, PFKFB3 knockdown decreased PFKFB3-specific transcripts by 50%, encouraging aggressive T cell infiltration with subsequent intense innate and adaptive inflammation, including TNFSF11 expression, indicating recruitment and retention of RANKL+ T cells and tissue production of IL- 1β, IL-6 and TNF (110). The gene discussed is TNFSF11; the disease is rheumatoid arthritis.