CD4 and myasthenia gravis: For instance, patients with myasthenia gravis (MG) treated with thymectomy have been previously studied, and similar results have been observed in the long term: a significant reduction in the number of TRECs, lower numbers of naïve CD4+ and CD8+ T cells along with an increased proportion of memory CD4+ T cells (48), decreased T cell counts and a reduced TCR repertoire (49).