Quercetin also has been reported to improve diabetes-related complications in in vivo mouse and rat studies by interfering with the innate signaling pathways such as TLRs and peroxisome proliferator-activated receptor ɣ (PPARɣ) and inhibiting the activity of nuclear factor κ light-chain enhancer of activated B cells (NF-κB) which subsequently reduces the levels of TNF and CRP (94–96). This evidence concerns the gene TNF and diabetes mellitus.