Figure 3D shows that both diseases even had differentiation of CD14++CD80+ cells and CD14++CD163+ cells in the IFP. Statistics on the mean (SD) of M1/M2 ratio as well as their proportions in CD14-positive cells in each group are shown in Supplementary Figures S3B, C. The cell numbers in each group are presented in Table 2. However, the M1/M2 ratio was 0.59 (0.31–1.11) and was found to be biased to the M2 phenotype in peripheral blood mononuclear cell from RA patients (26). This evidence concerns the gene CD163 and rheumatoid arthritis.