Figure 3D shows that both diseases even had differentiation of CD14++CD80+ cells and CD14++CD163+ cells in the IFP. Statistics on the mean (SD) of M1/M2 ratio as well as their proportions in CD14-positive cells in each group are shown in Supplementary Figures S3B, C. The cell numbers in each group are presented in Table 2. However, the M1/M2 ratio was 0.59 (0.31–1.11) and was found to be biased to the M2 phenotype in peripheral blood mononuclear cell from RA patients (26). Here, CD80 is linked to rheumatoid arthritis.