Our data demonstrated that, blocking galectin-receptor interactions exhibited increased liver histopathology and increased activity of Kupffer cells in the livers of malarial mice due to an increase in Kupffer cell numbers, which was associated with the upregulated levels of Gal-9, Tim-3, IFNα, IFNγ, and TREM-1 in the erythrocytic stage of malaria. This evidence concerns the gene LGALS9 and malaria.