STAT3 and skin disorder: In this study, immunofluorescence and qPCR analysis showed that MLT significantly reduced the infiltration of CD4+ T cells in rosacea-like dermatitis (Figures 6A, B) and suppressed the expression of Th1-related genes (IFN-γ, CCR5, CXCL9, CXCL10) and Th17-related genes (STAT3 and IL-20) (34) in rosacea-like dermatitis (Figure 6C).