Additionally, 51 KEGG pathways were significantly enriched (P-adjusted < 0.05), including the AGE-RAGE signaling pathway in diabetic complications, lipid metabolism and atherosclerosis, NF-kappa B signaling pathway, IL-17 signaling pathway, PPAR signaling pathway, and TNF signaling pathway (Figure 4B and Table S10). The gene discussed is TNF; the disease is atherosclerosis.