Moreover, studies demonstrated the potential relationship between MLT target genes (MMP9, CCND1, EGFR, ICAM1, PTGS2, and SERPINE1) and rosacea-related key genes (IL-6, IL-1β, IFNγ, IL-17, and TNF-α) (78, 79). The gene discussed is ICAM1; the disease is rosacea.