From a more clinical stand point, it was shown that the hypomorphic allele of the Ncf1 gene encoding for p47phox, a subunit of NOX2, is one of the strongest genetic predispositions for autoimmune arthritis, autoimmune encephalomyelitis and systemic lupus erythematosus (SLE), which are associated with increased numbers of autoreactive T cells (119–122). The gene discussed is CYBB; the disease is systemic lupus erythematosus.