TGFB1 and neoplasm: CAFs contribute to tumor growth by promoting the tumor angiogenesis by secreting VEGF and angiopoietin, by generating anti-apoptotic factors and by the secretion of chemokines (CCL2 and CCL5) and MMPs to promote the dissemination while blocking the immune response through the secretion of immunosuppressive cytokines IL-6, IL-10 and TGF-β (162–164).