S100A8 and atherosclerosis: In the presence of CXCL4, M0 Mφ changed to M4 Mφ, expressing CD206, CD68, matrix metallo proteinase (MMP) 7, myeloid-related protein 8 (MRP8) and S100A8, producing IL-6, TNF-α, MMP7, and MMP12 in atherosclerosis and cardiac remodeling (31–33).