IFN-γ+ NKT lymphocytes following IL-12 plus IL-18 stimulation in naïve MS (n=15) patients decreased from 6.49 ± 4.10% to 3.61 ± 2.39% in the presence of minocycline (p = 0.02) and to 2.52 ± 1.87% in the presence of doxycycline (p = 0.003) (Figure 3). This evidence concerns the gene IL18 and myeloid sarcoma.