ENO2 and hyperhomocysteinemia: After adjusting for all included clinical variables, the logistic regression analysis showed that smoking [OR, 6.774 (95% CI, 1.238–37.082); p = 0.027], increased HAMD score [OR, 1.074 (95% CI, 1.002–1.152); p = 0.045], hyperhomocysteinemia [OR, 2.815 (95% CI, 1.057–7.496); p = 0.038), elevated NSE level [OR, 1.069 (95% CI, 1.007–1.135); p = 0.03] were independently correlated with higher risk of SD in AE patients.