Multivariate analyses based on TMC5 expression (median as the cut-off to divide the patients into high- or low-group) and patient clinical characteristics in the three breast cancer cohorts (GSE11121, GSE45255, GSE6532) showed that the TMC5 expression was an independent prognostic biomarker for disease-free survival in breast cancer (Figure 4M). The gene discussed is TMC5; the disease is breast cancer.