Our data suggest that the efficacy of PARPi on bacterial clearance is specific for Mtb and does not translate to other intracellular bacteria, including the closely related species Mav. While not investigated here, this suggests that PARP is not a key target for MRSA, Stm and Mav, although the exact role of PARP during other bacterial infections remains to be resolved. The gene discussed is PARP1; the disease is bacterial infectious disease.