In addition, patients with GS-A patients are characterized by low expression of four high-risk lncRNA (H19, HOTAIRM1, AGAP2-AS1, AC002456.1) and one high-risk gene KRT8. GSEA showed that functional pathways involved in RTK8 were mainly immune cell and tumor-related signaling pathways, such as the T cell receptor, apoptosis, or JAK/STATA signaling pathway (Figures 6C–E). This evidence concerns the gene KRT8 and neoplasm.