We found that some genes with high combined score including TGFBR1-TGFBR2, JAG2-NOTCH2, ETS1-SP1, NRAS-PDGFRA, and BDNF-TRAF6 were mainly enriched in the “Human T-cell leukemia virus 1 infection,” “IL-17 signaling pathway,” “TGF-beta signaling pathway,” and “PD-L1 expression and PD-1 checkpoint pathway in cancer pathway.” Here, NOTCH2 is linked to cancer.