ST3GAL6-AS1 and SOX21-AS1 as protective factors have been reported in cancers, lncRNA ST3GAL6-AS1 overexpression significantly reduces colorectal cancer cell tumorigenesis and metastasis (29), and lncRNA SOX21-AS1 significantly suppresses tumorigenesis in cervical cancer (30), oral cancer (31), and GBM (32). This evidence concerns the gene SOX21 and glioblastoma.