In this regard, interferon lambda 4 (IFNL4) influences innate immunity regulation, and has been established as an aetiology-independent predictor of tissue inflammation and fibrosis (83), and more recently, IFNL4 has been associated with liver fibrosis in MAFLD patients most likely by modulating the activation of innate immunity and necroinflammation (84). The gene discussed is IFNL4; the disease is Hepatic fibrosis.