In recent years, Kanneganti et al. (2018) proved that FMF (a kind of systemic autoinflammatory diseases) model mouse by Clostridium difficile induces pyroptosis and promotes the secretion of IL-1β, and further in vivo experiment showed that the expression level of IL-1β was reduced and the organ-specific inflammatory injury, such as hepatitis, glomerulonephritis, and colitis was also relieved when GSDMD was knocked out. This evidence concerns the gene GSDMD and colitis.