To elucidate the transcriptional dynamics of SARS-CoV-2 in Vero E6 and Huh7 cell lines, we first standardized the viral gene counts by using host reference genes (BMS1, IWS1, and WDR33 for Huh7 and PPP2CB, SEL1L3, and HADH for Vero E6) and investigated the accumulation pattern of viral genes after infection. Here, PPP2CB is linked to infection.