ESR1 and invasive breast carcinoma: Consistent with previous studies on evaluating the risk factors of DM in patients with invasive breast cancer, patients with tumor size (>10 mm), ILC, estrogen receptor (ER), and progesterone receptor (PR) as well as Her-2-positive subtype, and Black race (Supplementary Figure S2) presented a higher risk of DM (12, 14, 21).