Heme oxygenase 1 (HO-1), also named heme oxygenase-1 (HO-1), expression upregulation in high glucose plus oxidized LDL-treated primary peritoneal macrophages from wild-type mice and Nrf2/HO-1 can be a therapeutic target for diabetic nephropathy (38, 39). The gene discussed is HMOX1; the disease is diabetic kidney disease.