In overweight or obesity MAFLD patients, total cholesterol, LDL-c, ApoB, ApoE, and Lp(a) achieved AUCs of 0.679, 0.677, 0.689, 0.684, and 0.674, respectively (all p < 0.02). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.