These support a close relationship between serum lipids and lipoprotein except for HDL-c, ApoA1, or Lp-a and LFC in overweight/obesity, with similar patterns in diabetes except for LDL-c and FFA, but show lost correlations between lipid markers and lean/normal weight phenotypes. This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.