Markers of endothelial activation and damage, such as ICAM-1, thrombomodulin (TM), tissue factor (TF), and tissue factor pathway inhibitor (TFPI), were associated with the number of lacunes and severity of leukoaraiosis in the cSVD group in a prospective series of patients suffering from a lacunar strokes (53). The gene discussed is THBD; the disease is Stroke.